The BCR signalling pathway also plays a crucial role in the pathogenesis of B-cell malignancies including chronic lymphocytic leukaemia (CLL), Waldenstrom’s macroglobulinemia (WM), mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL), driving abnormal proliferation and survival [3,4]. Here, BCR is linked to B-cell chronic lymphocytic leukemia.