Additionally, Toor et al. could demonstrate in a small and mixed cohort of stage I–IV colorectal cancer patients using a flow cytometry assay that LAG-3 expression on peripheral mononuclear leukocytes was significantly lower compared to the levels observed on both tumor-infiltrating lymphocytes (TILs) and lymphocytes from adjacent normal colon tissue (NILs). Here, LAG3 is linked to colorectal cancer.