LAG3 and neoplasm: The presence of LAG-3 expression on TILs either in the tumor front or tumor center was associated with better DFS (5-year DFS 89.9% (LAG-3 positive TILs) versus 74.7% (LAG-3 negative TILs), HR 0.34, 95% CI 0.14–0.80, p = 0.009; Figure 2A).