LAG3 and malignant colon neoplasm: The favorable association of LAG-3 expression on TILs either in the tumor front or tumor center with the outcome remained significant, even when we considered only MMR-proficient colon cancers (5-year DFS 90.2% versus 67.9%, HR 0.30, 95% CI 0.11–0.83, p = 0.014; Figure 3A).