BMI1 and Familial prostate cancer: Many studies have reported that high BMI1 expression is associated with poor prognosis in different types of malignancies, such as pancreatic adenocarcinoma, hepatocellular carcinoma, prostate cancer, nasopharyngeal cancer, endometrial adenocarcinoma, acute myeloid leukemia, and chronic myeloid leukemia [13,14,15,16,17,18,19,20].