IOS parameters deteriorated acutely after a session of EC in both groups.PEF and FEV1/FVC deteriorated significantly after a session of EC in patients with asthma but not in healthy controls.FeNO and Th2 cytokines (IL-4 and IL-13) increased significantly in asthmatic patients after an EC session compared with controls.IL-1β, TNF-α, IL-10 and ISO8 increased significantly in asthmatic patients after an EC session compared with controls. The gene discussed is IL1B; the disease is asthma.