Furthermore, we determined that elevated plasma misfolded proteins (p-Tau and Aβ-42) are correlated with lower scores on neuropsychological assessments (MMSE, arithmetic, DSC and ABS) and brain atrophy (RAA, cerebellum and caudate nuclei), indicating the effects of misfolded proteins on neurotoxicity, neuron damage, and brain volume loss. The gene discussed is MAPT; the disease is Brain atrophy.