This accumulation facilitates the production of autoantibodies, the generation of damaged cytosolic DNA and micronuclei that can act as powerful stimulators of the immune system by over-expression of the cGAS-STING-IRF3 path and the production of type I IFN, leading to the systemic expression of autoimmune diseases [3,14,32]. Here, STING1 is linked to autoimmune disease.