The defective DNA repair mechanism via OGG1, the reduced regulatory effect of sRAGE in the activation of AGE-RAGE axis, low levels of thiols, disulphide bonds formation and high nitrotyrosination are important characteristics of lupus nephritis in our study and they could explain alteration of renal architecture and development of renal injury in SLE. The gene discussed is OGG1; the disease is lupus nephritis.