As previously noted, particularly in 2016-E2020, trials initiated for hematologic cancers far exceeded those for solid tumors with most of the hematologic trials (90%) being CAR-Ts targeting either B-cell leukemias and lymphomas (404 out of 529 trials with 368 targeting CD19) or multiple myeloma (99 trials of which 85 target BCMA) (Figure 5A–C). The gene discussed is TNFRSF17; the disease is AL amyloidosis.