The specimens revealed mantle cell lymphoma, with immunohistochemistry stains positive for CD20 (Figure 2C), Bcl-2, cyclin D1 (Figure 2D), SRY-box transcription factor-11 (SOX-11), immunoglobulin D (IgD) and immunoglobulin M (IgM) but negative for CD3, CD5, CD10 and CD23. The gene discussed is CD5; the disease is mantle cell lymphoma.