Some germline variants of POT1 have also been described in families with chronic lymphatic leukemia [104], cardiac angiosarcoma and other tumor types in TP53-negative Li-Fraumeni-like syndrome [105], colorectal cancer [106], thyroid neoplasms [107], gliomas [108], breast cancer, and endometrial and small cell lung carcinomas [101]. Here, POT1 is linked to thyroid tumor.