PLG and intracranial hemorrhage: The mechanical injury of the brain tissue and its direct consequence, brain edema, the potential reparative and anti-inflammatory roles of microglia and macrophages in the later phase of the intracranial hemorrhage to resorb the bleeding and resolve the edema, or the release of thrombin, plasmin and reactive oxygen species that cause brain cell damage following intracranial hemorrhage, might differ between sexes [37,38,39].