EGF and leiomyoma: In the same manenr, Yoshida et al. observed suppressed expression of growth factors such as EGF, insulin-like growth factor 1 (IGF-1), TGFβ, and also angiogenic factors (VEGF, ADM) and their receptors in leiomyoma cells influenced by asoprisnil and CDB-2914 (ulipristal acetate) [55].