It has been accepted that in solid tumors including breast [12,13], ovarian [14,15], melanoma [16] and gastric [17] cancers, pDCs were shown to be largely dysfunctional with decreased capacity to produce IFNα and with induction of Tregs that produce IL-10 and TGFβ, which further support tumor progression [10]. This evidence concerns the gene TGFB1 and cancer.