ACS (HR 4.60, p = 0.003) was the strongest predictor of prolonged hospitalization followed by coexisting infections, (HR 2.61, p < 0.001), NT-proBNP > 1986 pg/mL (HR 1.96, p < 0.001), ADHF (HR 1.76, p = 0.002), presence of HFrEF (HR 1.69, p = 0.007) and increased HAS BLED score (HR 1.42, p < 0.001). This evidence concerns the gene NPPB and infection.