In our comparison of multi-RFA and hepatectomy, the ECOG status (p = 0.014), presence of comorbidities (p = 0.046), high tumor grade (p < 0.001), initial metastasis (p = 0.002), BRAF-mutated tumors (p = 0.015), and a history of RT (p = 0.002) were predictors of poorer OS. The gene discussed is BRAF; the disease is neoplasm.