Overall, patients with HH tend to be on the more severe end of the liver disease severity spectrum, as expressed by markers of liver function (bilirubin, INR, albumin, and sodium levels), decompensation profile (hepatic encephalopathy, hepato-renal syndrome, ACLF), and prognostic systems (MELD-Na, Child–Pugh, ALBI). This evidence concerns the gene ALB and hepatorenal syndrome.