TIMP2 and acute kidney injury: A systematic review and meta-analysis including 8 studies and a total of 552 cardiac surgery patients reported a reliable performance of [TIMP-2] × [IGFBP7] for the detection of CSA-AKI, with a pooled sensitivity of 0.79 (95% CI, 0.71–0.86, I2 = 74.2%), a specificity of 0.76 (95% CI, 0.72–0.80, I2 = 80.8%), and an area under the curve estimated by a summary receiver operating characteristic of 0.868 [50].