Another metabolic condition considered in the Obesity and Diabetes score was obesity, a highly prevalent disease in which excessive accumulation of adipose tissue, especially visceral adipose tissue, interferes with homeostasis by stimulating the release of inflammatory mediators such as interleukin-6, tumor necrosis factor, and other adipokines [25,26]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.