The panel of eight proteins identified as discriminating between the groups, and common at both 6- and 12-months post-surgery, included proteins known to be related to insulin sensitivity and glucose intolerance (TF, SHBG and PRG4) [28,29,30], relate to systemic inflammation (HSPA4 and APOA4) [31,32] ,also those involved in the immune response (LRG1 and PGLYRP2) [33,34,35,36] and cholesterol function (EPHX2) [37,38]. The gene discussed is PRG4; the disease is Glucose intolerance.