Both are currently used in treating autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjogren’s, but several studies have found that high levels of serum BAFF are associated with the formation of anti-HLA DSA, increased risk of AMR, and poor renal graft survival [134,135,136,137,138]. This evidence concerns the gene TNFSF13B and systemic lupus erythematosus.