This study concluded that plasma p-tau181 correlates with core fluid biomarkers of AD (CSF Aβ42/40, CSF t-tau, CSF NfL, and plasma NfL), as well as with atrophy in AD-related brain regions, including the temporal regions, angular and supramarginal gyri, and precuneus of both hemispheres (measured by MRI), and lower brain metabolism in temporoparietal regions (measured by FDG-PET) [90]. The gene discussed is NEFL; the disease is Alzheimer disease.