MAPT and Alzheimer disease: Genes that are present in chromosome 21 and are thought to promote AD pathology are involved in different molecular pathways: redox metabolism (SOD1), cholesterol metabolism (ABCG1), Aβ processing and clearance (CSTB, BACE2 and SYNJ1), tau phosphorylation (DYRK1A), mitochondrial dysfunction (RCAN), and inflammatory responses (S100B, IFNRs) [11].