PRL and hyperprolactinemia: If a clear reason for the hyperprolactinemia is lacking perhaps hyperprolactinemia in the severe range (>2200 mIU/L or >100 ng/mL) might be an appropriate cut-off to warrant dedicated pituitary imaging (6.7% of our cohort had a prolactin level in the severe range, including one patient with a microprolactinoma).