In a subanalysis of 35 untreated patients with primary hypertension, we found trends towards a negative correlation between serum sclerostin and peripheral systolic blood pressure (SBP) (mm Hg) (r = −0.323, p = 0.058), SBP Z-score (r = −0.299, p = 0.081), central systolic blood pressure (AoSBP) (mm Hg)) (r = −0.311, p = 0.069), central pulse pressure (AoPP (mm Hg)) (r = −0.292, p = 0.088), E-tracking pressure strain elasticity modulus (ET Ep) (r = −0.313, p = 0.067), and alkaline phosphatase (IU/L) (r = 318, p = 0.063). This evidence concerns the gene SOST and essential hypertension.