Although ER− and HER2+ tumors have shown evidence of immunogenicity, these types of inflammatory breast tumors are rare when compared to TNBC tumors, which are unique among breast cancer subtypes in having strong antigen expression and high stromal and tumor-infiltrating lymphocytes, parameters with a vital prognostic and predictive significance to immunotherapy and chemotherapy. The gene discussed is ERBB2; the disease is breast carcinoma.