After analysis of our findings, based on the higher risk of EC with a longer T2DM duration and a younger T2DM onset, as well as the higher risk when combinations with several oral glucose-lowering medications, with or without insulin, were used, we hypothesize that in diabetic women, the extent of insulin resistance and the severity of T2DM, rather than the effect of any specific medication, may be associated with EC risk. This evidence concerns the gene INS and type 2 diabetes mellitus.