However, a recent systematic review and meta-analysis from fourteen eligible articles demonstrated that the regular intake of EGCG-rich green tea had no significant effects on fasting blood glucose and insulin, HbA1c or HOMA-IR in T2D patients [78], which may be partially explained by the weak inhibition towards all three intestinal α-glucosidases shown in this study. Here, INS is linked to type 2 diabetes mellitus.