VEGFA and breast carcinoma: Hwanggeumchal sorghum phenolic extracts have also been shown to have an inhibitory effect on human breast cancer MDA-MB-231 cells and MC7 xenografts in mice, through modulating Jak/STAT pathways, hindering the STAT5b/IGF-1R and STAT3/VEGF pathways, and down-regulating the angiogenic factors, such as VEGF, VEGF-R2, and cell cycle regulators such as cyclin D, cyclin E, and pRb [55].