NOS2 and colitis: Accordingly, another colitis-induced mice model fed natural almond skin powder exhibited similar results on the prevention of intestinal inflammation, modulating the associated nuclear factor κB (NFκB) and c-Jun N-terminal kinase (JNK) signaling pathways, inhibiting enzymes such as iNOS and poly(ADP-ribose) polymerase (PARP), and decreasing the levels of leukocyte-activating markers intercellular adhesion molecule (ICAM-1) and P-selectin [55].