NFKB1 and colitis: Besides such colitis in vivo models, the ethanolic almond seed extracts were applied to renal cell carcinoma-induced rat models, demonstrating an inhibition of the cancer-related inflammatory process by decreasing pro-inflammatory CKs (IL-1β, IL-6, and TNF-α) levels, together with those of several inflammatory mediators (prostaglandin E2, PGE2, and NFκB) in a dose-dependent manner [54].