In the analysis of MMP-8 tests according to periodontal site diagnosis and severity, (a) MMP showed a higher level (median (interquartile range )) in periodontitis sites (357.6 (490.22 ng/mL)) in comparison to healthy sites (13.5 (62.11 ng/mL)), with statistically significant differences (p < 0.001). The gene discussed is MMP8; the disease is periodontitis.