Univariable Cox regression analysis (Table 3) pointed out that T1 stage was the only significant predictor of disease recurrence (HR: 2.60; p-value: 0.042) whereas presence of CIS (HR: 13.00; p-value: 0.001), EORTC score (HR: 1.19; p-value: 0.013) and Mfn2 down-regulation (HR: 9.54; p-value: 0.006) all emerged as significant predictors of disease progression. The gene discussed is MFN2; the disease is in situ carcinoma.