Amyloid plaques and neurofibrillary tangles are the neuropathological hallmarks of the disease [9,10], which can be evaluated in vivo by neuroimaging investigation and cerebrospinal fluid (CSF) biomarker assessment; namely, considering amyloidβ1-42 (Aβ42), its ratio with amyloid β1-40 (Aβ42/Aβ40), total tau protein (t-tau), and hyperphosphorylated tau (p-tau181). Here, MAPT is linked to amyloidosis.