Most of the AI models for AD are mainly built on biomarkers such as brain imaging, often with the use of Aβ and tau ligands, Aβ- or tau-PET, as well as biomarkers in CSF, which have high accuracy and predictive value; however, their invasive nature, high cost, and limited availability restrict their use to highly specialized centers [80,81,82,83]. The gene discussed is MAPT; the disease is Alzheimer disease.