There is a group of CDGs, including ALG12-CDG, ALG3-CDG, ALG9-CDG, ALG6-CDG, PGM3-CDG, CSGALNACT1-CDG, SLC35D1-CDG, and TMEM-165 with well-defined skeletal dysplasia. The gene discussed is TMEM165; the disease is skeletal dysplasia.