Among genes implicated in Ehlers-Danlos syndrome (EDS), biallelic mutations in B4GALT7 (encoding galactosyltransferase-I) have been described in patients affected with the progeroid form of EDS presenting with radioulnar synostosis, diffuse osteopenia, splaying of the ribs, broad thumbs and long fingers, long and overriding toes, equinovarus deformities, single palmar crease, and hypermobile joints (Table 1 and Table 2) [45,46,47,48]. The gene discussed is B4GALT7; the disease is Ehlers-Danlos syndrome.