GDF15 and Abnormal renal physiology: The present work suggests both serum and pericardial fluid GDF-15 as biomarkers of AKI in this subset of patients, which could be explained by both a decreased renal clearance of the biomarker, and increased expression in renal dysfunction, either in an acute setting or reflecting a subclinical previous kidney disease through early renal endothelial dysfunction [40,41,42].