RASSF1 and neoplasm: Again, according to the systematic reviews and meta-analyses by Ye et al. (2017), they concluded that methylation of RASSF1A promoter may be associated with the development, progression, and metastasis of NPC through the evaluation of the pooled sensitivity, specificity, and AUC of RASSF1A promoter methylation in NPC samples vs. non-tumor samples [45].