Hutajulu et al. (2011) reported that a panel of methylation biomarkers consisting of RASSF1A, CHFR, p16, RIZ1, and WIF1 showed high frequency of at least one methylated gene of NPC compared to individual markers, providing good discrimination between NPC and non-cancer [5]. This evidence concerns the gene RASSF1 and nasopharyngeal carcinoma.