The silencing of TSGs on chromosome 3p, including ADAM, BLU, DLEC1, GNAT1, LARS2, LTF, MLH1, RASSF1A, RAR-β, TIG1, VLH1, PTPRG, and ITGA9, by the phenomenon of DNA aberrant hypermethylation in NPC, seems to be the key role in the mechanism of NPC tumorigenesis, as reported. This evidence concerns the gene ITGA9 and nasopharyngeal carcinoma.