Yi et al. (2006) first identified that the downregulation of LTF was observed in 76% (25 of 33 cases) of primary NPC tissues, and the hypermethylation of LTF was observed in 63.6% (21 of 33 cases) of primary NPC samples, but not in chronic nasopharyngeal tissues. Here, LTF is linked to nasopharyngeal carcinoma.