Taking into account the fact that clinical usefulness of CRP and IL-6 concentration determination has not been unequivocally confirmed, and considering how little information is available on the determination of sCD40L concentration in patients with colorectal cancer, the aim of the current study was the evaluation of factors that may influence CRP, IL-6, and sCD40L concentrations in CRC patients. Here, CRP is linked to colorectal carcinoma.