In the CRC patients: (1) with an increase of PLT by 10 × 103/μL, the mean sCD40L concentration increases 1.023 times (increases by 2.3%); (2) with an MPC increase of 1 g/dL, the average concentration of sCD40L increases 1.15 times (increases by 15%); (3) with the WHO 2 grade, the mean sCD40L concentration increases 1.48 times relative to the WHO 1 grade (increases by 48%) (Table 4). This evidence concerns the gene CD40LG and colorectal carcinoma.