Mutations involved 3 channelopathy-associated genes (RYR2, CACNA1C, and ANK2), 3 HCM- or DCM-associated genes (MYH7, LDB3, and PRKAG2), 5 ACM-related genes (PKP2, JUP, DSG2, DSP, and TMEM43), and 2 cardiac transcription factor genes (TBX5 and GATA4). This evidence concerns the gene TBX5 and familial dilated cardiomyopathy.