CCL2 and periodontitis: The high levels of Interleukin-1β (IL-1β), IL-6, Interleukin-8 (IL-8), TNFα, and monocyte chemoattractant protein-1 (MCP-1) associated with periodontitis can induce a rapid hepatic synthesis and secretion of plasmatic vascular proteins such as CRP and fibrinogen [105,106].