TARDBP and motor neuron disorder: In patients with amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD), inclusions positive for the anti-TDP-43 antibody reaction are usually present, so the clinical and neuropathological designation of FTLD-MND-TDP (frontotemporal lobar degeneration with motor neuron disease and TDP-43 positive inclusions) is used.