Mentioned markers from the group of RNA-binding proteins in ALS are TDP-43, FUS, or hnRNPs, although some others can be used—TATA-box binding protein associated factor 15 (TAF15), which is mutated in both SALS and FALS; Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1 (EWSR1) with similar characteristics as FUS and TAF15 that they can easily aggregate leading to the toxicityn [133]; or ataxin-2 (ATXN2), which acts as a dose-sensitive modifier of TDP-43 toxic effect [134]. This evidence concerns the gene EWSR1 and amyotrophic lateral sclerosis.