It is probably not surprising that in genetic ALS-FTSD cases, SOD1- or FUS-immunoreactive inclusions can be found; moreover, alterations in microtubule-associated tau protein (tau) metabolism have been observed in ALS-FTSD, with the presence of tau deposits usually in the hyperphosphorylated form [92]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.