The existence of several peripheral forms of ghrelin as a result of splicing shows the complexity of this hormonal interaction [60], and studies reporting positive In1-ghrelin expression in neuroendocrine tumors compared with native ghrelin expression with the help of quantitative PCR assay strongly point to the potential role of In1-ghrelin as a prognostic marker [61]. This evidence concerns the gene GHRL and neuroendocrine neoplasm.