HDAC1 and clear cell renal carcinoma: Immunohistochemical analysis for HDAC-1 on tissue microarray (TMA) specimens of clear-cell renal-cell carcinoma (ccRCC) patients, revealed direct association of HDAC-1 overexpression with positive hypoxia inducible factor (HIF) isoforms (predominantly HIF1a/HIF2a) expression [71].