Following the significant association of TACI pathogenic defects with benign lymphoproliferation (splenomegaly, lymphadenopathy), history of adenoidectomy and tonsillectomy as well as the presence of hematological autoimmunity in the univariate analysis (Table 3), a series of stepwise multiple logistic regression analyses were performed. This evidence concerns the gene TNFRSF13B and Splenomegaly.