HVCN1 and alpha 1-antitrypsin deficiency: Due to the reported functional changes in AATD neutrophils, including increased chemotaxis [32], increased primary granule degranulation [25], delayed bacterial killing [33], and a recent study demonstrating alterations in the membrane proteome of circulating AATD neutrophils [29], we chose to explore the expression of membrane voltage-gated proton channel-1 (HVCN1).