Polycythemia vera, essential thrombocythemia and myelofibrosis share three common driver mutations: JAK2 V617F, CAL-R, and MPL are present in both myelofibrosis and essential thrombocythemia, while polycythemia vera harbors JAK2 V617F or mutations in the exon 12 of JAK2. This evidence concerns the gene CALR and acquired polycythemia vera.