Polycythemia vera, essential thrombocythemia and myelofibrosis share three common driver mutations: JAK2 V617F, CAL-R, and MPL are present in both myelofibrosis and essential thrombocythemia, while polycythemia vera harbors JAK2 V617F or mutations in the exon 12 of JAK2. Here, MPL is linked to myelofibrosis.