Specifically, the diagnosis of CEL-NOS requires: (a) peripheral eosinophils count of 1.5 × 109/L or more; (b) absence of WHO criteria for BCR-ABL1-positive chronic myeloid leukemia, PV, ET, PMF, CNL, CMML, or atypical CML; (c) absence of rearrangement of PDGFRA, PDGFRB, or FGFR1; no PCM1-JAK2, ETV6-JAK2, or BCR-JAK2 fusion gene; (d) blast count in peripheral blood or bone marrow <20% without diagnostic features of AML; (e) presence clonal cytogenetic or molecular genetic abnormality, or blast cells are ≥2% in the peripheral blood or >5% in the BM [1]. The gene discussed is JAK2; the disease is essential thrombocythemia.