Doxorubicin is most frequently accounted for HF [9], while ibrutinib for arrhythmias [10], 5-fluorouracil (5-FU) for coronary spasm, vascular endothelial growth factor (VEGF) inhibitors for arterial hypertension, and paclitaxel for conduction abnormalities. The gene discussed is VEGFA; the disease is hydrops fetalis.