When considering only the characteristics of each site regardless of the overall diagnosis of each patient, 12 gingivitis sites demonstrated a trend of more total Sclerostin in the GCF (148.18 ± 40.27 pg) (p = 0.09) when compared to 51 periodontitis sites (123.27 ± 19.08 pg) and 45 healthy sites (127.03 ± 46.86 pg) (Figure 1A). This evidence concerns the gene SOST and periodontitis.