WNT5A and periodontitis: As WNT-5a promotes osteoblast differentiation through the upregulation of LR5/6 {14,15}, WNT-5a sustains active osteoclastogenesis and bone destruction in an inflammatory environment (periodontitis sites), while in a noninflammatory environment of healthy sites, the pro-osteoblastic activity of WNT-5a prevails.