Compared with the normal group, patients in the osteopenia or osteoporosis groups were older (63.94 ± 8.89 vs. 70.25 ± 8.84 vs. 68.43 ± 7.09; p = 0.023) and had more females (35.4% vs. 75% vs. 85.7%, p = 0.002), higher levels of OPG (231.27 ± 82.47 vs. 413.87 ± 118.05 vs. 665.37 ± 191.45, p < 0.001), higher URR (0.73 ± 0.04 vs. 0.75 ± 0.04 vs. 0.76 ± 0.04; p = 0.021), and higher Kt/V (1.30 ± 0.16 vs. 1.41 ± 0.17 vs. 1.44 ± 0.17; p = 0.027) but lower BMI (25.92 ± 5.01 vs. 23.61 ± 3.94 vs. 20.26 ± 2.26, p = 0.006). Here, TNFRSF11B is linked to Osteopenia.