IFNA1 and chronic hepatitis B virus infection: Viral load, liver iron score and insulin resistance index seem to have a significant degree of predictability in terms of viral response to therapy in chronic hepatitis B. Indeed, patients with high viral load and high degree of insulin resistance were less likely to achieve a virological response in chronic hepatitis B treated with Peg IFN, regardless of age, BMI, hepatic cytolysis enzymes, cholesterol and triglycerides.