From the overall analysis of the above results, it appears that only HOMA index values, that of fasting insulin, together with baseline HBV DNA, ALT values, mean blood glucose at the beginning of treatment may be predictive of the early viral response in chronic hepatitis B. The limit values of the parameters that could anticipate the therapeutic success in chronic hepatitis B are shown in Table 8. This evidence concerns the gene INS and chronic hepatitis B virus infection.