REN and obesity due to melanocortin 4 receptor deficiency: Although the etiopathogenesis of obesity-associated hypertension via “renin-angiotensin-aldosterone system activation, increased secretion of leptin, insulin resistance, sympathetic nervous system stimulation and other biochemical active compounds” has been explained in previous reports, the pathophysiological mechanisms underlying obesity-related outcomes, including hypertension and other metabolic health disorders, are still unclear and need further studies.