Although current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, or a GFR below 60 mL/min/1.73 m2 or elevated urinary albumin-to-creatinine ratio above 300, the latest reports indicate that unlike in young adults where mortality is associated with impaired renal function increases already at GFR < 75 mL/min/1.73 m2, in older adults it increases only at GFR < 45 mL/min/1.73 m2 [19]. The gene discussed is ALB; the disease is chronic kidney disease.