In Ins2Akita mice, a mode of type 1 diabetes due to the spontaneous mutation in the insulin 2 gene, the hepatic expression levels of Cyp26a1, Rarb, Rdh10, and Rdh 13 are higher than that in the C57BL/6J control mice, which is associated with the increase in NAD+-dependent retinol dehydrogenase activities of microsome in the mutant mice, suggesting the interaction of VA metabolism and type 1 diabetes [70]. Here, CYP26A1 is linked to type 1 diabetes mellitus.