Among the cellular structures that are linked via plectin to IFs are all sorts of cytoskeletal junctional complexes, including hemidesmosomes (HDs) and focal adhesions (FAs) in epithelial cells and fibroblasts, costameres and neuromuscular junctions (NMJs) in myofibers, myelin sheath-stabilizing junctions of Schwann cells, penetrating invadopodial protrusions of metastatic cancer cells, and others (for details see [5,6,14,15]. Here, PLEC is linked to cancer.