In a study addressing physiological consequences of plectin accumulation observed at the sarcolemma of muscular dystrophy patients and mdx mice [95], the phenotyping of different plectin KO mouse lines in parallel revealed that, in subsarcolemmal regions of plectin-null myofibers, MT networks were more prominent, appearing more robust, compared to their wild-type counterparts. Here, PLEC is linked to muscular dystrophy.